C5a Receptor Deficiency Attenuates T Cell Function and Renal Disease in MRLlpr Mice
نویسندگان
چکیده
منابع مشابه
C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice.
The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. To characterize the role of C5a and its receptor (C5aR) in SLE, C5aR-deficient mice were backcrossed nine generations onto the lupus-like MRL(lpr) genetic background. Evidence is presented that C5aR modulates both renal injury and T cell responses in MRL(lpr) m...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2005
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2005040373